Journal of Cytology & Histology

Monika Orzeł

Publications

• Research Article
  P16/Ki67 Dual Immunostaining in Conventional Cytology in Women with Positive Papanicolau Test
  Author(s): Agnieszka Korolczuk, Monika Orzeł, Sławomir Woźniak, Agata Smoleń and Kinga CabanAgnieszka Korolczuk, Monika Orzeł, Sławomir Woźniak, Agata Smoleń and Kinga Caban
  
  Cytology-based screening has limited sensitivity to detect cervical precancerous lesion. Hihg risk human papilloma virus (HR HPV) DNA tests increase the detection of CIN II+ lesions, however it cannot differentiate if the infection is or transient or persistent. Its use is often limited by the need of standardisation of laboratory technics and relatively high costs. Recently, several studies analysed the diagnostic performance of p16/Ki67 dual-stained cytology as the possible alternative or coexisting option to HR HPV testing. In most of them the smear is obtained for liquid-based cytology. This study was designed to analyze the usefulness of p16/Ki67 dual immunostaining in conventional cytology, which is the method of choice in cervical cancer screening in our country. 68 women with positive Pap test results were selected. Colposcopy, cervical biopsy and HR HPV DNA tests were perform.. Read More»
  DOI: 10.4172/2157-7099.1000358

  Abstract PDF