Journal of Sports Medicine & Doping Studies

Morten Hostrup

Publications

• Research Article
  Urine Concentrations of Inhaled Salmeterol and its Metabolite a-Hydroxysalmeterol in Asthmatic and Non-Asthmatic Subjects
  
  Author(s): Morten Hostrup, Anders Kalsen, Jimmi Elers, John Henninge, Peter Hemmersbach, Kim Dalhoff, Lars Petersen and Vibeke BackerMorten Hostrup, Anders Kalsen, Jimmi Elers, John Henninge, Peter Hemmersbach, Kim Dalhoff, Lars Petersen and Vibeke Backer
  
  Salmeterol is a long-acting beta2-agonist, which is on the WADA prohibited list, but can be used by athletes in therapeutic doses by inhalation. The prohibited list, however, contains no urinary threshold for salmeterol, which gives athletes the opportunity to inhale unlimited doses of salmeterol. In doping controls, metabolites may be used as markers for misuse of substances. No studies have determined urine concentrations of α-hydroxysalmeterol, the metabolite of salmeterol. Furthermore, the metabolism and excretion of salmeterol may vary between asthmatics and nonasthmatics. We determined the serum and urinary concentrations of salmeterol and its metabolite α-hydroxysalmeterol after inhalation of 100 μg salmeterol in ten asthmatics and ten non-asthmatics. Blood samples were collected at baseline and ½, 1, 2, 3, 4 and 6 hours after the administration of salmetero.. Read More»
  DOI: 10.4172/2161-0673.1000110

  Abstract