Journal of Material Sciences & Engineering

Mostafa A

Publications

• Research Article
  Osteoinduction and Antiosteoporotic Performance of Hybrid Biomaterial Chitosan-Bioactive Glass Graft: Effects on Bone Remodeling
  Author(s): Jebahi S, Oudadesse H, Faouzi FZ, Elleuch J, Rebai T, Keskes H, Mostafa A, El Feki A and El Feki HJebahi S, Oudadesse H, Faouzi FZ, Elleuch J, Rebai T, Keskes H, Mostafa A, El Feki A and El Feki H
  
  Osteoinductive and antiosteroporotic phenomena could be created by using synthetic biomaterials for applications in bone surgery. In the present study, CH-based bioactive glass (BG-CH) with 17 wt% chitosan was elaborated by a freeze-drying process. BG-CH was implanted in the muscle and in the femoral condyles of ovariectomised rats. Grafted tissues were carefully removed for physico-chemical and histological analysis. Several physic-chemical techniques (XRD, FT-IR, MEB, ICP-OES and NMR) were employed to highlight the effects of chitosan on the glass matrix before and after implantation. The results of the study show that despite the non-additional osteogenic cells or agents, BG-CH is endowed with an osteoinductive property. After 8 weeks, 13C NMR spectra showed the characteristic signals of γ-carbons of the hydroxyproline (71 ppm) abundant in collagen... Read More»
  DOI: 10.4172/2169-0022.1000128

  Abstract PDF