Journal of Biometrics & Biostatistics

Muhamed Lisic

Publications

• Research Article
  Comparison of MLL Fusion Genes Expression among the Cytogenetics Abnormalities of Acute Myeloid Leukemia and Their Clinical Effects
  Author(s): Senol Dogan, Amina Kurtovic-Kozaric, Albenita Hajrovic, Muhamed Lisic and Ercan GokgozSenol Dogan, Amina Kurtovic-Kozaric, Albenita Hajrovic, Muhamed Lisic and Ercan Gokgoz
  
  Mixed-lineage leukemia (MLL) is a subtype of acute myeloid leukemia with more aggressive prognosis than other subtypes. Translocations of MLL gene with other partner genes, forming the MLL-fusion proteins (MLL-FPs), are the main characteristics of MLL leukemia. Many studies have demonstrated that MLL-FPs such as: MLL-AF4, MLL-AF6, MLL-AF9, MLL-AF10, MLL-ENL, MLL-ELL, MLL-EPS15, as well as partial tandem duplication are the most common abnormalities that play significant role in MLL-rearranged leukemia. Gene expression profiles from 197 patients and 180 clinical data were downloaded from TCGA database. R statistical program has classified clinical and genomic data simultaneously according to cytogenetic abnormalities. As a result of this analysis, the most frequent 47 MLLFPs genes expression have been detected and compared with other cytogenetic abnormaliti.. Read More»
  DOI: 10.4172/2155-6180.1000312

  Abstract PDF