Pharmaceutical Regulatory Affairs: Open Access

Mukesh C Sharma

Publications

• Research Article
  Theoretical Studies of Substituted N-(1H-Benzimidazol-2ylmethyl)-5,6,7,8-Tetrahydro-8-Quinolinamines as CXCR4 Antagonists: QSAR Approach
  Author(s): Mukesh C SharmaMukesh C Sharma
  
  To identify the essential structural requirements in 2D chemical space for the modulation of the CXCR4 antagonists of Substituted N-(1H-benzimidazol-2ylmethyl)5,6,7,8-tetrahydro-8-quinolinamines. The statistically significant model showed an internal predictive power of 81 % and a predictivity for the external test set of about 79%. It reveals that carbon chain connected should be directly attached with benzimidazole ring for maximal determining activity. Three QSAR models were developed for substituted tetrahydro-8-quinolinam.. Read More»
  DOI: 10.4172/2167-7689.1000146

  Abstract PDF