Journal of Health & Medical Informatics

Mukesh C Sharma

Publications

• Research Article
  Predictive Activity Modeling of 2-Substituent-1H-Benzimidazole-4- Carboxamide Derivatives against Enteroviruses using QSAR Approach
  Author(s): Mukesh C SharmaMukesh C Sharma
  
  Abstract The present study was focused on development of the potential compound containing 2-substituent-1Hbenzimidazole- 4-carboxamide derivatives against enteroviruses using QSAR studies. We discussed the twodimensional QSAR studies of 2-substituent-1H-benzimidazole-4-carboxamide analogues to elucidate the structural properties required for enteroviruses activity. The 2D-QSAR studies were performed using multiple linear regressions, giving square of correlation coefficient (r2)=0.7458, cross validated squared correlation coefficient (q2)=0.7128 and predictable ability (pred_r2)=0.7092. The present study reveals that presence of less bulky group at R1 position of benzimidazole scaffold increase the enteroviruses activity. We hope that the current study provides better insight into the designing and development of more potent benzimidazole-4-carboxamide inhibi.. Read More»
  DOI: 10.4172/2157-7420.1000187

  Abstract PDF