Journal of Clinical Case Reports

Mustafa Jafri

Publications

• Case Report
  Severe Refractory Hypocalcemia in a Patient with Metastatic Prostate Carcinoma Following Denosumab Injection
  Author(s): Naveed Ali, Salman Farhat, Syed Imran, Mustafa Jafri, Aamir Ahmed and Faizan MalikNaveed Ali, Salman Farhat, Syed Imran, Mustafa Jafri, Aamir Ahmed and Faizan Malik
  
  An 86-year-old male with a history of metastatic castrate sensitive prostate cancer received a single dose of Denosumab for his bony metastases. Two weeks later, he presented to the hospital due to left foot cellulitis and was incidentally found to have profound hypocalcemia whereas his serum calcium was normal at the time of Denosumab injection. A thorough workup was undertaken which showed severe Vitamin D deficiency. He was diagnosed with Denosumab induced hypocalcemia with underlying Vitamin D deficiency which was refractory to supplemental calcium and Vitamin D. This case demonstrates the potential of Denosumab to cause profound hypocalcemia which can be resistant to therapy. Bone metastasis is a common clinical encounter and Denosumab is an effective therapy to prevent skeletal related events (SRE). Therefore, given its widespre.. Read More»
  DOI: 10.4172/2165-7920.1000830

  Abstract PDF