Journal of Diabetic Complications & Medicine

Nagalaxmi V

Publications

• Research Article
  UV-B Exposure Increases the Activity of Indoleamine 2, 3-Dioxygenase (Ido) and Alters the Levels of Tryptophan Metabolites in Indian Ground Squirrel (Funambulus Palmarum) Lens
  Author(s): Nagalaxmi V, Praveen Kumar M, Sashidhar RB and Turlapati Naga RajuNagalaxmi V, Praveen Kumar M, Sashidhar RB and Turlapati Naga Raju
  
  The ocular lens of the ground squirrel is an excellent model for studies of eye light interactions that may apply to the human system. UV-B radiation induced damage to the eye lens is believed to be mediated through ROS Antioxidant systems, both enzymatic and non- enzymatic aid in preventing the damage to the lens. The activity of indoleamine 2,3- dioxygenase (IDO), a first rate limiting enzyme of tryptophan catabolism, has been studied in the lenses of Indian ground squirrel exposed to UV-B radiation. Further, antioxidants and oxidative stress markers have also been investigated to assess the oxidative status. Our investigation revealed an increased indoleamine 2,3-dioxygenase activity and tryptophan metabolites suggesting their protective role in UV stress. The study indicates that UV-B irradiation for 12 h and 24 h (300 nm; 100 μw/cm2) of lens samples led to a m.. Read More»
  DOI: 10.4172/2475-3211.1000102

  Abstract PDF