Medicinal Chemistry

Nagendra Sastry Yarla

Publications

• Research Article
  Synthesis of Putrescine Bisamides as Antimicrobial and Anti-Inflammatory Agents
  Author(s): Srinuvasarao Rayavarapu, Sunanda Kumari Kadiri, Mahaboob Basha Gajula, Mangarao Nakka, Ramu Tadikonda, Nagendra Sastry Yarla and Siddaiah VidavalurSrinuvasarao Rayavarapu, Sunanda Kumari Kadiri, Mahaboob Basha Gajula, Mangarao Nakka, Ramu Tadikonda, Nagendra Sastry Yarla and Siddaiah Vidavalur
  
  A new naturally occurring N1, N6-dihydrocinnamyl putrescine bisamide, JBIR-94, along with nine structural analogs and a series of substituted phenyl and alkyl putrescine bisamides have been synthesized from putrescine and appropriately substituted carboxylic acids, through carboxylic acid chlorides. Antimicrobial, 5-Lipooxygenase enzyme inhibitory and antioxidant studies were performed for all synthesized compounds. Dihydrocinnamyl series of putrescine bisamides (4a-4i) showed good bioactivities compared to substituted phenyl (6a-6g) and diakyl (6h-6j) series of compounds. Among all compounds, 4h (methylenedioxy analog) and 4a (JBIR-94) showed good antimicrobial, antiinflammatoryand antioxidant activities. .. Read More»
  DOI: 10.4172/2161-0444.1000167

  Abstract PDF