Cancer Science & Therapy

Nagy MA

Publications

• Review Article
  HIF-1 is the Commander of Gateways to Cancer
  Author(s): Nagy MANagy MA
  
  The hypoxia-inducible factor-1 (HIF-1) is primarily involved in the sensing and adapting of cells to changes in the O2 level, which is essential for their viability. An increased activity is recognized in the majority of clinical relevant hypoxic/ischemic episodes and human cancers .HIF-1 is considered a central regulator of the adaptation response of cancer cells to hypoxia that makes it a therapeutic target in solid tumors. In this article, the biochemical pathways that are regulated by HIF-1 and the factors that regulate HIF-1 expression are briefly discussed .as targeting HIF-1, may selectively kill tumor cells that adapt to low O2 concentrations... Read More»
  DOI: 10.4172/1948-5956.1000054

  Abstract PDF