Medicinal Chemistry

Najma Sultan

Publications

• Research Article
  RP-HPLC Method for the Simultaneous Determination of Captopril and H₂-Receptor Antagonist: Application to Interaction Studies
  Author(s): Najma Sultan, Safila Naveed and M Saeed ArayneNajma Sultan, Safila Naveed and M Saeed Arayne
  
  Rapid, sensitive, simple and accurate high-performance liquid chromatographic (HPLC) method is developed and validated for the simultaneous determination of captopril with H2 receptor antagonists as cimetidine, ranitidine and famotidine. Captopril was separated from H2 receptor antagonist using pre packed Purospher star C18 (5 μm, 25×0.46 cm) column methanol: water (60:40 v/v) were used as the mobile phase, pH 3.0 ± 0.02 was adjusted by orthophosphoric acid. The flow rate was 0.8 mLmin-1 at ambient temperature, diluent was 50:50 methanol water while UV detection was performed at 225 nm. The retention time for captopril was found to be 5.2 minute, for ranitidine and famotidine 2.5 minute and cimetidine 2.7 minute. Each drug showed a good resolution from captopril. In vitro interaction studies of captopril with commonly administered H2 receptor antagonists i.e. cimetidin.. Read More»
  DOI: 10.4172/2161-0444.1000136

  Abstract PDF