Journal of Bioanalysis & Biomedicine

Najma Sultana

Publications

• Research Article
  Charge Transfer Complexes of Gamma Aminobutyric Acid-Analogue, A Neurotransmitter: Synthesis and Spectrophotometric Determination
  Author(s): Najma Sultana, Muhammad Saeed Arayne and Saeeda Nadir AliNajma Sultana, Muhammad Saeed Arayne and Saeeda Nadir Ali
  
  Here, we report spectrophotometric method for the determination of gabapentin through charge transfer complexes with σ and π acceptors and also with dye stuffs. The method involves ion-pair complex formation of gabapentin with ninhydrin, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, tetracyanoethylene, methyl orange and picric acid. The optimum conditions for the reactions and validation of described procedure have been studied. Resulting complexes absorb at 580, 315, 340, 464 and 342 nm in the Beer’s law range of 2-22, 32-80, 40-360, 12-96 and 15-135 μg mL-1 with correlation coefficient greater than 0.998 in each case respectively. The proposed method was applied successfully for the determination of gabapentin in pharmaceutical formulations. Satisfactory recovery values suggest that the method is reliable for the determination of gabapentin in pharmaceutical formulati.. Read More»
  DOI: 10.4172/1948-593X.1000075

  Abstract PDF