Cancer Science & Therapy

Naoya Arai

Publications

• Research Article
  Constitutive Activation of Caspase-3 in Non-Apoptotic Oral Squamous Cell Carcinoma Cells
  Author(s): Wataru Heshiki, Kei Tomihara, Manabu Yamazaki, Naoya Arai, Kenji Nakamori and Makoto NoguchiWataru Heshiki, Kei Tomihara, Manabu Yamazaki, Naoya Arai, Kenji Nakamori and Makoto Noguchi
  
  Background: Although caspase-3 is a key molecule for apoptosis induction, recent evidence has suggested its protumoral role in various human malignancies. The aim of the present study was to investigate the expression of cleaved caspase-3 (the active form of caspase-3) in both clinical samples and cell lines from oral squamous cell carcinomas (OSCCs) and elaborate on its contribution to the protumor role in oral cancer. Methods: The expression of cleaved caspase-3 was immunohistochemically evaluated in samples from 30 patients with OSCCs. The samples were either from biopsies or surgically-resected specimens with a mix of clinical stages and tumor site origins. The expression of cleaved caspase-3 was further examined in three OSCC cell lines. .. Read More»
  DOI: 10.4172/1948-5956.1000328

  Abstract PDF