Molecular Biology: Open Access

Naseer Maliyakkal

Publications

• Research Article
  Protocatechualdehyde Induces Apoptosis in Human Non-Small-Cell Lung Cancer Cells by up Regulation of Growth Arrest and DNA Damage-Inducible (GADD) Genes
  Author(s): Satyajit Patra, Roshan Mascarenhas, Naseer Maliyakkal and Jesil Mathew AranjaniSatyajit Patra, Roshan Mascarenhas, Naseer Maliyakkal and Jesil Mathew Aranjani
  
  Growth arrest and DNA damage-inducible (GADD) 45 and GADD153 proteins have been implicated in DNA repair, cell cycle regulation and growth arrest along with numerous other cellular mechanisms. In recent years, evidence has emerged that proteins encoded by these genes play pivotal roles in tumor suppression and apoptotic cell death. Thus, compounds altering the expression of these genes are likely to be of interest in cancer prevention and/or treatment. Protocatechualdehyde is isolated from Phellinus gilvus and has been investigated as a promising cancer preventive agent because of its medicinal properties. This mushroom belongs to Hymenochaetaceae Basidiomycetes, and has advantages over many Phellinus species due to short growth period (3 months), making production cost-effective. The exact molecular mechanisms of protocatechualdehyde are not clearly underst.. Read More»
  DOI: 10.4172/2168-9547.1000113

  Abstract PDF