Journal of Antimicrobial Agents

Nayak BB

Publications

• Research Article
  Antimicrobial Compounds of Plant Origin as Efflux Pump Inhibitors: New Avenues for Controlling Multidrug Resistant Pathogens
  Author(s): Rao M, Padyana S, Dipin KM, Kumar S, Nayak BB and Varela MFRao M, Padyana S, Dipin KM, Kumar S, Nayak BB and Varela MF
  
  The emergence of multiple drug resistant pathogenic bacteria has severely constricted the antimicrobial options of treating infectious diseases. One of the powerful mechanisms of antibacterial resistance employed by the antibiotic resistant bacteria is the active extrusion of antimicrobials with the help of membrane transporters known as efflux pumps. Efflux pumps effectively reduce the intracellular concentrations of antimicrobials by their antiporter activity in which antimicrobials are extruded outside the bacterial cell using energy derived from ionic gradient across the cell membrane. While a few efflux pumps are capable of conferring clinical levels of resistance to antibiotics, while many others only marginally increase the minimum inhibitory concentrations (MIC) of antibiotics. However, the role of efflux pumps in gradual development of antibiotic resistance by pathogenic bact.. Read More»
  DOI: 10.4172/2472-1212.1000159

  Abstract PDF