Pulmonary & Respiratory Medicine

Neveen Abd El-Moneum Hassan

Publications

• Research Article
  Matrix Metalloproteinase-9 (MMP-9) and Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) as Non-Invasive Biomarkers of Remodelling in Asthma
  Author(s): Neveen Abd El-Moneum Hassan, Aliaё Abd-Rabou Mohamed-Hussein, Ebtssam F. Mohammed, Omnia Abd El-Moneum Mohamed, Hanan O Mohamed and Manal Mohamed Tammam MahmoudNeveen Abd El-Moneum Hassan, Aliaё Abd-Rabou Mohamed-Hussein, Ebtssam F. Mohammed, Omnia Abd El-Moneum Mohamed, Hanan O Mohamed and Manal Mohamed Tammam Mahmoud
  
  Rationale: Airway remodelling is clinically defined as persistent airflow obstruction despite aggressive antiinflammatory therapies. Assessment of airway remodelling by analysis of serum markers has been developed as minimally invasive procedures. Aim of the work: Evaluate the usefulness of estimation of serum MMP-9, TIMP-1 and their ratio, as non-invasive markers of airway remodelling in asthmatics. Patients and methods: The study included 68 asthmatics and 20 controls. Patients were classified according to levels of asthma control, severity and disease duration. Serum samples were taken to estimate levels of MMP-9, TIMP-1 and their ratio. Results: Serum MMP-9, TIMP-1, and MMP-9/TIMP-1 were significantly higher in asthmatics than controls, in uncontrolled vs. controlled asthma (P<0.001). Also they were significantly higher in severe a.. Read More»
  DOI: 10.4172/2161-105X.1000266

  Abstract PDF