Saudi Arabia
Research Article
Effect of Moringa oleifera Leaves on Diclofenac Sodium Induced Hepatic Injury in Albino Rats: Ultrastructural and Immunohistochemical Studies
Author(s): Nevine Refaat Taha, Samar O Rabah, Soad A Shaker and Maysoon M MograbyNevine Refaat Taha, Samar O Rabah, Soad A Shaker and Maysoon M Mograby
Objective: This study was conducted to investigate the possible hepatoprotective role of Moringa oleifera leaves extract known by its phenolic antioxidant components against acute hepatic injury induced by different doses of Diclofenac sodium (DIC) in albino rats.
Materials and methods: Ninety male albino rats of 200-250 gm were sorted into 9 groups each with 10 rats: group1serves as control received orally normal saline, group 2 received a dose of 8 mg/kg DIC orally for 15 days, groups 4, 6, 8 received (50, 100, 150 mg/kg) DIC orally for 3 days, groups 3,5,7,9 received orally Moringa oleifera leaves extract (500 mg/kg) before the different DIC doses. At the end of the experiments, blood was collected for assessment of liver functions, pieces from right lobe of the liver were sectioned and stained for light and ultrastructural studies.
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DOI:
10.4172/2157-7099.1000315
Journal of Cytology & Histology received 2476 citations as per Google Scholar report