Journal of Antimicrobial Agents

Newton PJ

Publications

• Research Article
  Assessment of Posaconazole Salvage Therapy in Chronic Pulmonary Aspergillosis by Using Predefined Response Criteria
  Author(s): Goncer IR, Harris C, Kosmidis C, Muldoon EG, Newton PJ and Denning DWGoncer IR, Harris C, Kosmidis C, Muldoon EG, Newton PJ and Denning DW
  
  Objective: Chronic pulmonary aspergillosis (CPA) is a progressive infection that destroys lung tissue in immune competent patients. First-line therapies for CPA (itraconazole and/or voriconazole) are often curtailed due to toxicity or the development of drug resistance. Posaconazole is a potential alternative for these patients, but it is a high-cost medication. Methods: Use of posaconazole was funded by the NHS Highly Specialised National Commissioners on an individual basis for patients who failed or did not tolerate first line therapy; those who met predefined criteria for improvement at 4 and 6 months (weight gain and/or improvement in St George’s Respiratory Questionnaire) continued posaconazole long-term. We recorded response, failure, discontinuation rates and adverse events. Results: Seventy-eight patients .. Read More»
  DOI: 10.4172/2472-1212.1000158

  Abstract PDF