Journal of Cytology & Histology

Nicholas Thatcher

Publications

• Research Article
  NAD(P)H:Quinone Oxidoreductase 1 Expression in Human Primary Melanotic Melanomas of the Skin
  Author(s): Francesco Zappa, Timothy Ward, Ennio Pedrinis, AIan Mc Gown and Nicholas ThatcherFrancesco Zappa, Timothy Ward, Ennio Pedrinis, AIan Mc Gown and Nicholas Thatcher
  
  NAD(P)H:quinone oxidoreductase 1 (NQ01; DT-diaphorase; DTD) is a two-electron reducing enzyme which is often over-expressed in cancers and can activate quinones to form cytotoxic species. This over-expression is used as target in the design of novel anti-cancer drugs. DTD is also expressed in normal tissues, but little is known about its “body mapping”. Because of the dearth of information on the cell-specific expression of DTD in pigmentproducing cells of the skin, we analysed its expression in normal and tumoral samples. Twenty skin biopsies of primary malignant melanotic melanomas (ten with vertical invasion, ten with superficial spreading) were analysed by immunohistochemistry. In normal skin DTD expression was weak in all epidermal layers, including normal melanocytes. Malignant melanomas showed a very strong DTD expression in tumoral cells of all samples and in endot.. Read More»
  DOI: 10.4172/2157-7099.1000259

  Abstract PDF