Journal of Computer Science & Systems Biology

Nicola Bernabo

Publications

• Review Article
  Computational Modeling of Spermatozoa Signal Transduction Pathways: Just a Computer Game or a Reliable Tool in Studying Male Gametes Function?
  
  Author(s): Nicola Bernabo, Mauro Mattioli and Barbara BarboniNicola Bernabo, Mauro Mattioli and Barbara Barboni
  
  Mammalian spermatozoa gain their fertilizing ability only after they reside within the female genital tract, where important physical-chemical modifications, the “capacitation”, occur: the cytoskeleton reorganizes, the membranes become more instable and tend to fuse each other, the protein phosphorylation pattern changes, a new motility pattern, the hyperactivated motility, appears. These events are regulated by several signal transduction pathways, whose failure could have negative implication for fertility. Unfortunately, frequently it is impossible to issue a diagnosis, as in the case of “idiopathic infertility”. In our opinion, this inability could be not due to the scarcity of molecular data, but to the difficulty to manage them. Indeed, spermatozoa (like other cells) are constituted by heterogeneous components that interact co.. Read More»
  DOI: 10.4172/jcsb.1000117

  Abstract