Journal of Bioprocessing & Biotechniques

Nicole Borth

Publications

• Review Article
  Investigation of CHO Secretome: Potential Way to Improve Recombinant Protein Production from Bioprocess
  Author(s): Susmita Chaudhuri, Priyanka Maurya, Manpreet Kaur, Ashutosh Tiwari, Nicole Borth, Shinjini Bhatnagar and Niraj KumarSusmita Chaudhuri, Priyanka Maurya, Manpreet Kaur, Ashutosh Tiwari, Nicole Borth, Shinjini Bhatnagar and Niraj Kumar
  
  The demand for recombinant protein therapeutics is increasing worldwide and hence improvements in the overall yield of such products from bioprocess are of great interest to make them affordable. Chinese Hamster Ovary (CHO) cells are the most commonly used cell lines for large scale production of such high-quality (human-like) recombinant protein products. Typically, product is released, along other secretory proteins, by the cell into the culture media. These secreted proteins may have significant impact on cell growth, product quality & quantity during the production culture and the designing of strategies for efficient product purification. However, only few efforts have been made to date to explore these secreted proteins (the “secretome”), although significant technological advancements have been witnessed in the field of proteomics du.. Read More»
  DOI: 10.4172/2155-9821.1000240

  Abstract PDF