Journal of Computer Science & Systems Biology

Nidhi Trivedi

Publications

• Research Article
  Subtractive Genomics Approach for in Silico Identification and Characterization of Novel Drug Targets in Neisseria Meningitides Serogroup B
  Author(s): Aditya Narayan Sarangi, Rakesh Aggarwal, Qamar Rahman and Nidhi TrivediAditya Narayan Sarangi, Rakesh Aggarwal, Qamar Rahman and Nidhi Trivedi
  
  Meningococcal disease is a life-threatening illness with annual incidence rates varying from 1 to 1000 per 100 000 persons in different parts of the world. Effective polysaccharide and polysaccharide-protein conjugate vaccines that offer protection against infection with meningococcal serogroups A, C, Y and W-135 have been licensed and are available worldwide. Serogroup B remains the most prevalent cause of meningococcal disease responsible for 32% of all meningococcal disease in the United States, 45 to 80% of the cases in Europe, and for the majority of cases in the rest of the world. The development of a vaccine against serogroup B poses the biggest problem due to the similarity between the B capsular polysaccharide structure and a polysialic acid containing glycopeptides that are a part of human brain tissue. Prevention of meningococcal disease will re.. Read More»
  DOI: 10.4172/jcsb.1000038

  Abstract PDF