Journal of Hypertension: Open Access

Niels-Henrik Holstein-Rathlou

Publications

• Research Article
  Oscillator Suppression in the Blood Flow Regulation of Interacting, Non- Identical Nephrons
  Author(s): Yulia P Emelianova, Alexander P Kuznetsov, Jakob L Laugesen, Erik Mosekilde and Niels-Henrik Holstein-RathlouYulia P Emelianova, Alexander P Kuznetsov, Jakob L Laugesen, Erik Mosekilde and Niels-Henrik Holstein-Rathlou
  
  Background: Regulation of the blood flow to the individual functional unit (nephron) of the kidney involves a feedback mechanism that produces large-amplitude oscillations in the blood flow itself as well as in the intra-nephron pressures and flows. Neighboring nephrons adjust their blood flow variations relative to one another via signals that propagate along the interconnecting blood vessels. Purpose and method: Using a detailed physiological-based model of a pair of vascular coupled, non-identical nephrons, the paper examines the effect that their relative oscillatory strength has on the behavior of the coupled system. This is of direct interest in connection with ongoing work attempting to study the synchronization behavior for larger groups of superficial nephrons by means of laser speckle contrast imaging. Results:.. Read More»
  DOI: 10.4172/2167-1095.1000153

  Abstract PDF