Journal of AIDS & Clinical Research

Nigel J Klein

Publications

• Research Article
  Body Fat Accumulation is Associated with Early Arterial Changes in HIVInfected Children
  Author(s): Marietta Charakida, Agnieszka B Dzwonek, Vas Novelli and Nigel J KleinMarietta Charakida, Agnieszka B Dzwonek, Vas Novelli and Nigel J Klein
  
  Background: Antiretroviral therapy (ART) has greatly improved clinical outcomes in human immunodeciency virus (HIV) infection in adults and children. However, emerging data link ART to clinical lipodystrophy and premature atherosclerosis. We examined the impact of body fat changes on blood pressure and endothelial function in HIV infected children with and without ART. Methods: Central and peripheral body fat distribution was assessed in 68 HIV infected children. In all children blood pressure was measured and high resolution ultrasound was used to determine endothelium dependent dilatation (flow mediated dilatation-FMD) in the brachial artery. Results: From the 68 HIV infected children, 46 were on ART. There was no evidence of clinical lipodystrophy with ART in this cohort. Total cholesterol was increased in children on ART (p<0.001). FMD was significantly lower in those on ART co.. Read More»
  DOI: 10.4172/2155-6113.1000356

  Abstract PDF