Molecular Biomarkers & Diagnosis

Nikunj Tanna

Publications

• Research Article
  Clinical Validation of a Serum Protein Panel (FLNA, FLNB and KRT19) for Diagnosis of Prostate Cancer
  Author(s): Shobha Ravipaty, Wenfang Wu, Aditee Dalvi, Nikunj Tanna, Joe Andreazi, Tracey Friss, Allison Klotz, Chenchen Liao, Jeonifer Garren, Sally Schofield, Eleftherios P Diamandis, Eric A Klein, Albert Dobi, Shiv Srivastava, Poornima Tekumalla, Michael A Kiebish, Vivek Vishnudas, Ranga Prasad Sarangarajan, Niven R Narain and Viatcheslav R AkmaevShobha Ravipaty, Wenfang Wu, Aditee Dalvi, Nikunj Tanna, Joe Andreazi, Tracey Friss, Allison Klotz, Chenchen Liao, Jeonifer Garren, Sally Schofield, Eleftherios P Diamandis, Eric A Klein, Albert Dobi, Shiv Srivastava, Poornima Tekumalla, Michael A Kiebish, Vivek Vishnudas, Ranga Prasad Sarangarajan, Niven R Narain and Viatcheslav R Akmaev
  
  This study reports on the development of a novel serum protein panel of three prostate cancer biomarkers, Filamin A, Filamin B and Keratin-19 (FLNA, FLNB and KRT19) using multivariate models for disease screening and prognosis. ELISA and IPMRM (LC-MS/MS) based assays were developed and analytically validated by quantitative measurements of the biomarkers in serum. Retrospectively collected and clinically annotated serum samples with PSA values and Gleason scores were analyzed from subjects who underwent prostate biopsy, and showed no evidence of cancer with or without indication of prostatic hyperplasia, or had a definitive pathology diagnosis of prostatic adenocarcinoma. Probit linear regression models were used to combine the analytes into score functions to address the following clinical questions: does the biomarker test augment PSA for population screening? Can aggressive disease.. Read More»
  DOI: 10.4172/2155-9929.1000323

  Abstract PDF