Journal of Computer Science & Systems Biology

Nilkanth J. Faldu

Publications

• Research Article
  Molecular Docking Studies of Antimalarial Drugs for Malaria
  Author(s): Nutan Prakash, Shivani Patel, Nilkanth J. Faldu, Ravi Ranjan and DVN SudheerNutan Prakash, Shivani Patel, Nilkanth J. Faldu, Ravi Ranjan and DVN Sudheer
  
  Malaria is the most important parasitic disease in humans, with transmission occurring in over 100 countries with a population of three billion people. It is caused by protozoan parasites of the genus Plasmodium. These parasites are transmitted from one person to another by the female anopheles mosquito. Proguanil is a prophylactic antimalarial drug, it stops the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase. The side effects of these drugs make the need for the necessity of new improved drugs Conformational analysis and geometry optimization of Proguanil was performed using Argus Lab & Hex software. When the receptor (DHFR) was docked with the drug Proguanil the energy value obtained was (-6.59) using Argus Lab and (-174.5.. Read More»
  DOI: 10.4172/jcsb.1000059

  Abstract PDF