Journal of Hypertension: Open Access

Nobuhito Hirawa

Publications

• Research Article
  Hypoalbuminemia and Hyperalbuminuria as Major Factors Regulating Circadian Blood Pressure Rhythm in Normal Subjects and Non-diabetic Patients with Early Stages of Chronic Kidney Disease
  Author(s): Gen Yasuda, Daisaku Ando and Nobuhito HirawaGen Yasuda, Daisaku Ando and Nobuhito Hirawa
  
  Study background: Albuminuria and nighttime blood pressure (BP) elevation are notable risk markers of chronic kidney disease (CKD). In non-diabetic patients with albuminuria, the effect of albuminuria on nocturnal BP and other risk factors that may disrupt circadian BP rhythm remain unclear. The aim of this study was to evaluate the relationship among albuminuria, serum albumin level and 24-hour BP rhythm in non-diabetic subjects. Methods: This prospective study enrolled 778 subjects (aged 20-80 years, estimated glomerular filtration rate ≥ 60 mL/min/1.73 m2). Main outcome measure was sleeping/waking mean BP (MBP) ratio as an indicator of circadian BP rhythm. First, a cross-sectional study was performed in all individuals showing no proteinuria. Second, a study was done in subjects never treated for hypertension (hypertensive-naïve) .. Read More»
  DOI: 10.4172/2167-1095.1000142

  Abstract PDF