Journal of AIDS & Clinical Research

Nogueira MB

Publications

• Short Communication
  IL28B and ITPA Single Nucleotide Polymorphisms in a Cohort of Patients with HCV and HCV/HIV, Southern Brazil
  Author(s): Avanzi VM, Vicente BA, Gomes-da-Silva MM, Vidal LRR, Nogueira MB, Tuon FF and Raboni SMAvanzi VM, Vicente BA, Gomes-da-Silva MM, Vidal LRR, Nogueira MB, Tuon FF and Raboni SM
  
  Objective: The aim of this study is to describe the single nucleotide polymorphisms (SNP) in human genes for IL28B and ITPA of HIV/HCV coinfected patients followed at a referral Hospital of Universidade Federal do Paraná (UFPR). Methods: A cross-sectional study was carried out. HIV/HCV coinfected and HCV monoinfected patients were enrolled. Clinical and epidemiological data from medical records were reviewed, and peripheral blood was collected to analyze the IL28B and ITPA SNPs. Results: A total of 37 HCV- and 41 HCV/HIV-positive subjects were included in the study, 13 (35.1%) monoinfected subjects were previously treated, 12 (92.3%) with PEG-INFα/RBV and of these, 8 (61.5%) had sustained virological response (SVR). Regarding HCV/HIV coinfected patients, 23 (56.1%) received treatment with PEG-INFα/RBV and 12 (52.1%) had SVR. IL28B CC genotype was found in all HCV mon.. Read More»
  DOI: 10.4172/2155-6113.1000610

  Abstract PDF