Egypt
Research Article
Ameliorated Effects of Verapamil on Hepatotoxicity Induced by Ethanol and Carbon Tetrachloride
Author(s): Hanaa Fathy Waer, Nomani Abdelhamid Nomani and Eman Rizk ElbealyHanaa Fathy Waer, Nomani Abdelhamid Nomani and Eman Rizk Elbealy
Background: Liver fibrosis progresses to cirrhosis in several settings for example, alcoholic hepatitis and produce hepatocellular dysfunction, which is also a risk factor for hepatocellular carcinoma. Aim: This study was designated to investigate the potential toxicity of CCl4 initiated by ethanol- as hepatotoxic agents on liver cellular structure glycogen, DNA contents and certain enzymes, and also to evaluate the preventive effect of a certain calcium ions antagonist like verapamil on carbon tetrachloride and ethyl alcohol-induced liver cellular injury in rats.
Materials and methods: Sixty healthy adult male albino rats weighing from 200-220 grams were used in this study. Animals were divided into 4 groups, each consisted of 15 rats: the first was considered the normal control, Group 2 was considered the model control which was given ethanol.. Read More»
DOI:
10.4172/2157-7099.1000142
Journal of Cytology & Histology received 2334 citations as per Google Scholar report