Molecular Biomarkers & Diagnosis

Noraesah B Mahmud

Publications

• Review Article
  The Free Alpha-Hemoglobin: A Promising Biomarker for β-Thalassemia
  Author(s): Uday YH Abdullah, Ahmed GF Al-Attraqchi, Hishamshah M Ibrahim, Zilfalil Bin Alwi, Atif A Baig, Iekhsan Othman, Noraesah B Mahmud, Rosline B Hassan, Nor Hedayah A Bakar and Alawiyah B A Abd RahmanUday YH Abdullah, Ahmed GF Al-Attraqchi, Hishamshah M Ibrahim, Zilfalil Bin Alwi, Atif A Baig, Iekhsan Othman, Noraesah B Mahmud, Rosline B Hassan, Nor Hedayah A Bakar and Alawiyah B A Abd Rahman
  
  The purpose is to review the current knowledge and methods of determination of the free alpha hemoglobin with emphasis on its potential implications in patients with beta-thalassemia (β-thal).The severity of β-thal correlates with the extent of imbalance between α- and non-α-globin chains and the amount of the free alpha hemoglobin (free α- Hb) pool in the erythrocytes. To date, there is a lack of biomarkers that convey diagnostic and prognostic values in β-thal. Our ongoing research is aimed to evaluate the potential prognostic and diagnostic implications of free α-Hb to improve the care of patients with β-thal. Our ongoing research is aimed to quantify the free α-Hb for its potential prognostic and diagnosticimplications towards improving the care of patients with various β-thal types in the years to come. .. Read More»
  DOI: 10.4172/2155-9929.1000197

  Abstract PDF