Molecular Biomarkers & Diagnosis

Noriyuki Kasai

Publications

• Research Article
  Soluble Heparin-Binding EGF-Like Growth Factor (HB-EGF) is a Potential Serological Biomarker for Various Cancer Types
  Author(s): Noriyuki Kasai, Yukitaka Yoshikawa, Kazuhiro Kobayashi, Shinobu Shioya, Shingo Miyamoto, Eisuke Mekada and Junichi EnokizonoNoriyuki Kasai, Yukitaka Yoshikawa, Kazuhiro Kobayashi, Shinobu Shioya, Shingo Miyamoto, Eisuke Mekada and Junichi Enokizono
  
  Background: Heparin-binding EGF-like Growth Factor (HB-EGF), a member of the EGF family, exerts its biological activity through activation of the EGF receptors. HB-EGF is initially synthesized as a membrane-anchored precursor protein (proHB-EGF), and then proteolytically cleaved, resulting in the mitogenically active soluble form. HB-EGF plays pivotal roles in many physiologic and pathologic processes such as development and cell proliferation. In this study, we measured soluble HB-EGF concentrations in serum samples obtained from healthy volunteers and patients of various cancer types. Materials and methods: Soluble HB-EGF levels in human serum samples were quantified by the immuno-PCR method. Results: The mean soluble HB-EGF levels of the 20 healthy volunteers and 10 colon, breast, ovarian, head and neck, non-small c.. Read More»
  DOI: 10.4172/2155-9929.1000158

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