Journal of AIDS & Clinical Research

Norman J Haughey

Publications

• Research Article
  Polyamines: Predictive Biomarker for HIV-Associated Neurocognitive Disorders
  Author(s): Salim Merali, Carlos A Barrero, Ned C Sacktor, Norman J Haughey, Prasun K Datta, Dianne Langford and Kamel KhaliliSalim Merali, Carlos A Barrero, Ned C Sacktor, Norman J Haughey, Prasun K Datta, Dianne Langford and Kamel Khalili
  
  Objectives: Spermidine/spermine-N1-acetytransferase (SSAT) is the key enzyme in the catabolism of polyamines that are involved in regulating NMDA functioning. Over expression of SSAT leads to abnormal metabolic cycling and may disrupt NMDA receptor signaling. In fact, the HIV protein Tat induces neurotoxicity involving polyamine/NMDA receptor interactions. Thus, we investigated abnormal polyamine cycling in HIV+ participants with varying degrees of HIV-associated neurocognitive disorders. Methods: Acetyl-polyamine (SSAT products) levels were assessed by HPLC in CSF from 99 HIV-infected participants (no cognitive impairment (NCI, n=25), asymptomatic neurocognitive impairment (ANI, n=25), mild cognitive and motor disorders (MCMD, n=24), and HIV-associated dementia (HAD, n=25)). Polyamine levels in brain tissues from a subset of participants (uninfected (n=3), NCI (n=3), and MNCD.. Read More»
  DOI: 10.4172/2155-6113.1000312

  Abstract PDF