Neurological Disorders

Norreel JC

Publications

• Research Article
  Blocking Nogo Receptor 1 Promotes Functional Regeneration after Spinal Cord Injury
  Author(s): Mezler M, Moeller A, Mueller BK, Meyer AH, Schmidt MK, Ghayur T, Barlow E, Labkovsky B, Devanarayan V, Norreel JC and Mueller RMezler M, Moeller A, Mueller BK, Meyer AH, Schmidt MK, Ghayur T, Barlow E, Labkovsky B, Devanarayan V, Norreel JC and Mueller R
  
  An insult to the mammalian spinal cord often results in persistent functional deficits. Proteins in CNS myelin are important determinants of this situation as they inhibit neurite growth. Among those proteins Nogo-A, oligodendrocyte myelin glycoprotein (OMgp), and myelin-associated glycoprotein (MAG) all bind to the neuronal Nogo-66 receptor (NgR1) and thereby block neuronal regeneration after injury. Neutralizing the interaction between the inhibitory ligands and NgR1 may alleviate the inhibition and therefore result in increased recovery after injury. Thus, antibodies neutralizing ligand/receptor interaction might have therapeutic value. From a set of 300 monoclonal anti-NgR1 antibodies one anti-NgR1 ligand blocking antibody (mAb50) was selected for in vivo studies. mAb50 binds with high affinity (below 100 pM) to human and rat NgR1, competes for binding of a ligand peptid.. Read More»
  DOI: 10.4172/2329-6895.1000128

  Abstract PDF