Journal of Cytology & Histology

Oguzhan Karatepe

Publications

• Research Article
  The Effect of Erythropoietin on Ischemic Colitis: An Experimental Rodent Model: Original Article
  Author(s): Oguzhan Karatepe, Idris Kurtulus, Orcun Unal, Orhan Yalcin, Ahu Kemik, Gulcin Kamali, Gokhan Adas, Muharrem Battal, Mine Adas, Hale Ozgun and Murat AksoyOguzhan Karatepe, Idris Kurtulus, Orcun Unal, Orhan Yalcin, Ahu Kemik, Gulcin Kamali, Gokhan Adas, Muharrem Battal, Mine Adas, Hale Ozgun and Murat Aksoy
  
  Background: Erythropoietin (Epo), a hormone produced by the kidney that promotes the formation of red blood cells in the bone marrow, is considered anti-inflammatory,anti-apoptotic, angiogenetic and sitoprotective. In this study, high dose erythropoietin is examined on an animal model for ischemic colitis (IC) to detect its possible potential benefits. Methods: Thirty female Wistar albino rats weighing 250-300 g were randomized into three experimental groups as follows: in Group 1, animals were sham operated (n = 10) and received distilled water; in Groups 2 and 3, the rats underwent a standardized surgical procedure to induce IC (n = 10 in each group). Group 2 animals served as the controls, receiving only tap water, while Group 3 animals received 3000 IU/kg eritropoetin as a single high dose. All animals were sacrificed 72 h after devascularization. Colonic malondialdehyde (MDA) l.. Read More»
  DOI: 10.4172/2157-7099.1000108

  Abstract PDF