Nuclear Medicine & Radiation Therapy

Oliver Sartor

Publications

• Research Article
  Targeted use of Alpha Particles: Current Status in Cancer Therapeutics
  Author(s): Oliver Sartor, Bassam N Maalouf, Carlin R Hauck and Roger M MacklisOliver Sartor, Bassam N Maalouf, Carlin R Hauck and Roger M Macklis
  
  Purpose of review: To summarize the current role of alpha particles in cancer treatment including both clinical and pre-clinical data. Recent findings: Though discovered more than hundred years ago, no targeted alpha emitters have yet to be approved as a systemic approach to cancer therapy. Until recently, most approaches to target alpha particle emitters utilized conjugation with antibodies through chelators. Limited clinical data are available using this approach; most alpha emitters have been studied in pre-clinical models though 213bismuth has been studied in leukemic patients. The novel alpha emitter 223radium has been studied more extensively than other agents in this class and a recent large randomized phase III trial data with 223radium demonstrates overall survival benefit in castrate resistant prostate cancer patients with skeletal metastasis. .. Read More»
  DOI: 10.4172/2155-9619.1000136

  Abstract PDF