Journal of Bioanalysis & Biomedicine

Omar Elmalak

Publications

• Research Article
  31 P-NMR and Differential Scanning Calorimetry Studies for Determining Vesicle�¢����s Drug Physical State and Fraction in Alendronate Liposomes
  Author(s): Eyal Afergan, Yousef Najajreh, Dikla Gutman, Hila Epstein, Omar Elmalak and Gershon GolombEyal Afergan, Yousef Najajreh, Dikla Gutman, Hila Epstein, Omar Elmalak and Gershon Golomb
  
  Background: A liposomal delivery system requires a complete understanding of the physicochemical characteristics of the drug– liposome system in order to predict their behavior and stability in-vitro and in-vivo . Objectives: Develop a rapid and simple experimental method to determine the fractions of the drug, alendronate (ALN), encapsulated and as a free form distributed in the liposomal suspension, and the physical state of the encapsulated drug. Methods: 31 P-NMR measurements utilizing Ga +3 as a shifting reagent in comparison to HPLC determinations, theoretical calculations and differential scanning calorimetry (DSC) studies of various liposomal ALN formulations. Results: The 31 P-NMR demonstrated that titrating liposomal ALN with increasing amounts of Ga +3 induced a sign.. Read More»
  DOI: 10.4172/1948-593X.1000035

  Abstract PDF