Journal of Cytology & Histology

Omar Feres

Publications

• Research Article
  CHK2 Immunohistochemical Expression in Colon Cancer and its Relation with Clinicopathological Features and Outcome in Metastatic Colon Cancer Patients
  Author(s): Karen Bento Ribeiro, Juliana da Silva Zanetti, Alfredo Ribeiro Silva, Fabiana Pansani, Sergio Britto Garcia, Omar Feres, José Joaquim Ribeiro da Rocha and Fernanda Maris PeriaKaren Bento Ribeiro, Juliana da Silva Zanetti, Alfredo Ribeiro Silva, Fabiana Pansani, Sergio Britto Garcia, Omar Feres, José Joaquim Ribeiro da Rocha and Fernanda Maris Peria
  
  Background: The DNA damage checkpoint pathway has been of interest to the field of cancer biology, since checkpoint defects result in the accumulation of altered genetic information, a central feature of carcinogenesis. Little is known about the role that CHK2 (checkpoint kinase 2) gene plays in colorectal cancer tumorigenesis. The purpose of this study was to evaluate CHK2 expression in metastatic colon cancer and correlate it with clinicopathological features and patient survival. Methods: Tissues of primary tumors were obtained from 58 patients with metastatic colon cancer. The tissue microarray immunohistochemistry was the technique used to evaluate CHK2 expression. Statistical analysis used was SPSS17; p-value was set at <0.050. The relationship between the CHK2 immunohistochemical expression and the patients’ clinical and pathol.. Read More»
  DOI: 10.4172/2157-7099.1000288

  Abstract PDF