Journal of Clinical Case Reports

Pablo Fernández- Crehuet

Publications

• Research Article
  Experience with Subcutaneous Methotrexate for the Treatment of Moderate-to-Severe Psoriasis
  Author(s): Ricardo Ruiz- Villaverde, Daniel Sánchez- Cano, Cristina Garrido- Colmenero and Pablo Fernández- CrehuetRicardo Ruiz- Villaverde, Daniel Sánchez- Cano, Cristina Garrido- Colmenero and Pablo Fernández- Crehuet
  
  Background: Clinical studies in patients with rheumatoid arthritis indicate that subcutaneous methotrexate exhibits a better pharmacokinetic profile than oral methotrexate, and this was associated with greater efficacy. Based on these findings, subcutaneous methotrexate may offer similar advantages for the treatment of psoriasis; however, this has not been previously evaluated. Aims: To determine the effectiveness of subcutaneous methotrexate (Metoject®) in patients with moderate-tosevere psoriasis vulgaris. Study design: Descriptive, single center case-series Methods: The study enrolled 10 patients with moderate-to-severe psoriasis who presented at the outpatient dermatology clinic. Treatment comprised 15 mg of subcutaneous methotrexate, once weekly for 6 months. Data were obtained on demographic characteristics (Table 1), durati.. Read More»
  DOI: 10.4172/2165-7920.1000558

  Abstract PDF