Journal of Computer Science & Systems Biology

Padmanaban K

Publications

• Research Article
  A Phylogenetic Approach for Assigning Function of Hypothetical Proteins in photorhabdus luminescens Subsp. laumondii TT01 Genome
  Author(s): Razia M, Karthik Raja R, Padmanaban K, Sivaramakrishnan S and Chellapandi PRazia M, Karthik Raja R, Padmanaban K, Sivaramakrishnan S and Chellapandi P
  
  Polyketides are larger family of structurally diverse natural products with a broad range of biological activity. The occurrence of polyketide synthase gene family/cluster in bacteria is capable to synthesis the polyketides. In this study, sequence and structural similarities of some hypothetical proteins of Photorhabdus luminescens subsp. laumondii TT01 analyzed to assign the functional relationship with polyketide synthases (PKSs) using bioinformatics tools. Many hypothetical proteins of this organism have shown homologies to PKS family on which a significant homolog found to be located at genomic region 2247626-2249476 bp in chromosome 1 carrying identical function. On searching motif and domain, it showed a strong similarity to ketoacyl (KA) synthase I and then to acyl carrier protein. The ketosynthaseacyltransferasedidomain module 5 (2HG4) of Saccharo.. Read More»
  DOI: 10.4172/jcsb.1000051

  Abstract PDF