N.Y Tasgaonkar institute of Medical Science and Research,
Karjat, 410201
India
Research Article
The Review of Small Size Silver Nanoparticle Neurotoxicity: A Repeat Study
Author(s): Pani Jyoti Prakash, Singh Royana, Pani Sankarsan and Shrivastav RajeevPani Jyoti Prakash, Singh Royana, Pani Sankarsan and Shrivastav Rajeev
Repeated oral gavages silver nanoparticle colloidal solution ingestion procedures for AgNps neural toxicity have been investigated in Swiss albino mouse fetuses’ brain at the ultra-structural (TEM) level by transmission electron microscopy and Nikon bright field microscopy. Transmission electron microscopy probe identified neural toxicity in the brain of mice fetuses in the form of mitochondrial autophagy, dysmorphology & dysfunction of cellular organelles vacuolization of neuronal cell, blood brain barrier inflammation, astrocytic swelling, Gliosis and a well visualized differentiation to the reaction products. Multiple reaction product localization was visible in the form of smaller size silver nano particles (1 to 20 nm range) percolation and perimembranous multiple patchy condensations focuses appeared from inside and outside of neuronal cell membrane. Histologically cel.. Read More»
DOI:
10.4172/2157-7099.1000468
Journal of Cytology & Histology received 2476 citations as per Google Scholar report