Journal of Blood & Lymph

Paolo Conca

Publications

• Case Report
  Recurrent Pulmonary Embolism and Pulmonary Hypertension in a Patient with �Ž�²-Thalassemia Intermedia
  Author(s): Antonella Tufano, Adriana Gianno, Antonio Coppola, Roberta Esposito, Paolo Conca, Gianmarco Alcidi, Nicoletta Franco, Mariateresa Polimeno, Michele D’Alto, Maurizio Galderisi and Giovanni Di MinnoAntonella Tufano, Adriana Gianno, Antonio Coppola, Roberta Esposito, Paolo Conca, Gianmarco Alcidi, Nicoletta Franco, Mariateresa Polimeno, Michele D’Alto, Maurizio Galderisi and Giovanni Di Minno
  
  Patients with β-thalassemia intermedia are at increased risk of thromboembolic events and multifactorial pulmonary arterial hypertension. A pro-thrombotic state, including decreased levels of natural anticoagulant proteins and chronic platelet activation, has been shown in these patients, in particular after splenectomy. We report the case of a 54-year-old splenectomized β-thalassemic patient with a history of unprovoked deep venous (femoro-politeal) thrombosis, complicated by a pulmonary embolism event at the age of 37, recurrent episodes of superficial vein thrombosis of the lower limbs with leg ulcers, and a progressive severe pulmonary arterial hypertension, related to recurrences of pulmonary embolism, despite long-term, well conducted oral anticoagulant treatment (vitamin K antagonists and apixaban). After the performance of a right heart catheterization, pul.. Read More»
  DOI: 10.4172/2165-7831.1000205

  Abstract PDF