Journal of Clinical Case Reports

Papi L

Publications

• Case Report
  Primary Ampullary Adenocarcinoma and Von Recklinghausen’s Disease: A Rare Association
  Author(s): Taddei A, Messerini L, Papi L, Castiglione F, Ringressi MN and Bechi PTaddei A, Messerini L, Papi L, Castiglione F, Ringressi MN and Bechi P
  
  Objective: Neurofibromatosis type 1 (NF1) is an autosomal dominant inherited disease. Although only a minority of NF1 patients develops malignancy as a complication of the disorder, cancer (mainly represented by tumors involving the nervous system) remains an important cause of morbidity and mortality. A case of the rare association between adenocarcinoma of the Vater ampulla and NF-1 is here reported. The patient accepted Whipple operation. Histologic analysis of the whole surgical specimen revealed an adenocarcinoma limited to the ampulla of Vater, without lymphonodal involvement. Methods: A study of the possible presence of genetic alterations, which could demonstrate a molecular correlation between NF-1 and periampullary epithelial neoplasms, was performed using the intragenic NF1 m.. Read More»
  DOI: 10.4172/2165-7920.1000760

  Abstract PDF