Journal of AIDS & Clinical Research

Patricio E Ray

Publications

• Research Article
  Expression of a Secreted Fibroblast Growth Factor Binding Protein-1 (FGFBP1) in Angioproliferative Kaposi Sarcoma
  Author(s): Patricio E Ray, Ali Al-Attar, Xue-Hui Liu, Jharna R Das, Elena Tassi and Anton WellsteinPatricio E Ray, Ali Al-Attar, Xue-Hui Liu, Jharna R Das, Elena Tassi and Anton Wellstein
  
  Objective: Kaposi’s sarcoma (KS) is an angioproliferative disease frequently seen in patients with the acquired immunodeficiency syndrome (AIDS). Previous studies suggest that the HIV-1 protein Tat and Fibroblast Growth Factor 2 (FGF-2) have synergistic angiogenic effects in AIDS-KS tumors. However, the mechanisms by which FGF-2 is released and activated in KS tumors are not clearly defined. We carried out this study to determine whether an FGFbinding protein (FGFBP1 or BP1) that enhances the angiogenic activity of FGF-2 is expressed in AIDS-KS tumors, and to define whether BP1, FGF-2, and HIV-Tat protein-protein interactions could play a potential clinically role in the pathogenesis of AIDS-KS. Methods: BP1 was localized in AIDS-KS lesions by immunohistochemistry and in situ hybridization studies. The binding of radiolabeled FGF-2 to His-tagged BP1 or the FGF-receptor 1.. Read More»
  DOI: 10.4172/2155-6113.1000309

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