Molecular and Genetic Medicine

Patricio Gariglio

Publications

• Review Article
  Role of HR-HPVs E6 and E7 Oncoproteins in Cervical Carcinogenesis
  Author(s): Patricio Gariglio, Jorge Organista-Nava and Elizabeth Alvarez-RiosPatricio Gariglio, Jorge Organista-Nava and Elizabeth Alvarez-Rios
  
  The strategies that High Risk Human Papillomavirus (HR-HPVs) have developed in differentiating epithelial cells to reach a DNA-synthesis competent state are basically related to the overexpression of the E6 and E7 oncoproteins and the cellular regulatory pathways that are targeted by them. These are basically related to hallmarks of cancer, and include sustaining proliferative signals, the evasion of growth suppression and immune destruction, replicative immortality, inflammation, invasion, metastasis and angiogenesis, as well as genome instability, resisting cell death and deregulation of cellular energetics. In this minireview, we summarize some of the biological activities of HVP16 E6 and E7 oncoproteins in cervical carcinogenesis. From this, it is evident that cervical cancer may represent an important model to understand the different oncogenic mechanisms and processes involved n.. Read More»
  

  Abstract PDF