Biosensors & Bioelectronics

Peng Chen

Publications

• Research Article
  Detection of DNA Damage Response Caused by Different Forms of Titanium Dioxide Nanoparticles using Sensor Cells
  Author(s): Peng Chen and Akiyoshi TaniguchiPeng Chen and Akiyoshi Taniguchi
  
  Titanium dioxide nanoparticles (TiO2 NPs) are generally considered to be biologically inert. However, TiO2 occurs in several crystalline forms, the two most common being rutile and anatase. Although both forms are tetragonal, the different crystalline forms give rise to different physical and chemical characteristics such as hardness, refractive index and photocatalytic ability. We hypothesized that the two forms of TiO2 NPs would also elicit different cellular responses. Three cell-based biosensors, using B-cell Translocation Gene 2 (BTG2), heat shock protein70B' (HSP70B') and nuclear factor kappa B (NF-кB) sensor cells, were used to determine if the different forms of TiO2 NPs cause different cellular responses. The cellular responses induced by TiO2 NPs were detected using HSP70B' and NF-кB sensor cells; we found that the different form.. Read More»
  DOI: 10.4172/2155-6210.1000129

  Abstract PDF