Journal of Antimicrobial Agents

Pereira MR

Publications

• Case Report
  Polymyxin B use Associated with Severe Hypotensive Episodes
  Author(s): Mehta M, Baron JM, Nelson BC, Muir J and Pereira MRMehta M, Baron JM, Nelson BC, Muir J and Pereira MR
  
  Polymyxin B was developed in the 1940s but was infrequently used because of renal toxicity. Since the rise of infections due to multidrug resistant gram-negative organisms, polymyxin B has re-emerged as an important agent. However, its toxicity is still not fully elucidated. In this report, we describe two cases of multiple hypotensive events occurring after polymyxin B administration. Management strategies, such as slowing the infusion rate and administering diphenhydramine, did not mitigate the hypotension. We also describe relatively high polymyxin levels correlated with this effect in one of these cases. .. Read More»
  DOI: 10.4172/2472-1212.1000102

  Abstract PDF