Cancer Science & Therapy

Petr Otahal

Publications

• Review Article
  Second Primary Tumours of the Head and Neck are not Associated With Adverse Overall Survival in Oral Sccs
  Author(s): Rostam Dariush Farhadieh, Petr Otahal, Kiarash Taghavi, Arash Salardini, Pamela Russell and Robert SmeeRostam Dariush Farhadieh, Petr Otahal, Kiarash Taghavi, Arash Salardini, Pamela Russell and Robert Smee
  
  Objective: Second primary tumours (SPT) have been implicated in the dismal overall survival (OS) of head and neck Squamous cell carcinomas (HNSCC). The incidence of SPT, the SPT diagnostic time-lag and the impact on OS were assessed. Subjects and methods: 363 consecutive patients treated for primary Oral SCCs (1967-2004) were analyzed retrospectively in this study. 95.1% and 90.5% of patients reached a minimum follow-up period of 3 and 5 years respectively. Results: Of 363 patients; 68 (18.7%) were diagnosed with metachronous SPT, 49 (13.5%) developed upper aerodigestive tract (UAD)-SPT, 28 (7.7%) were diagnosed with HNSCC-SPT, and 21 (5.8%) developed lung or esophageal carcinoma. Patients with subsequent HNSCC-SPT had a better median survival during follow-up than those not diagnosed with SPTs (p=0.0018). The rate of mortality in these patients showed a substantial increase compared .. Read More»
  DOI: 10.4172/1948-5956.1000053

  Abstract PDF