Cancer Science & Therapy

Philip Hoffman

Publications

• Research Article
  Sustained Oligoclonal T Cell Expansion Correlates with Durable Response to Immune Checkpoint Blockade in Lung Cancer
  Author(s): Sope Olugbile, Jae-Hyun Park, Philip Hoffman, Livia Szeto, Jyoti Patel, Wickii T Vigneswaran, Everett Vokes, Yusuke Nakamura and Kazuma KiyotaniSope Olugbile, Jae-Hyun Park, Philip Hoffman, Livia Szeto, Jyoti Patel, Wickii T Vigneswaran, Everett Vokes, Yusuke Nakamura and Kazuma Kiyotani
  
  Purpose: Antibodies that target immune checkpoint molecules have demonstrated significant and durable clinical benefit through re-activation and proliferation of pre-existing tumor-infiltrating CD8+ T cells in a broad range of tumor types including lung cancer. Detailed characterization of T cell dynamics at clonal levels using nextgeneration T cell receptor (TCR) sequencing in large cohorts of lung cancer patients is yet reported. Methods: We performed TCR sequencing of peripheral blood samples (and some tumors) obtained from 27 lung cancer patients undergoing single/combined immune checkpoint blockade therapies. Results: In one responder, we found expansion of a single T cell clone (approximately 20% of the all TCR reads) in a metastatic subcutaneous lesion that showed pathologic complete response on day 17 of treatmen.. Read More»
  DOI: 10.4172/1948-5956.1000497

  Abstract PDF