Molecular and Genetic Medicine

Philomène LS

Publications

• Research Article
  Arg Allele of P53 Gene Codon72 is a Risk Factor for Breast Cancer in Senegalese Women
  Author(s): Yacouba D, Demba DJP, Rokhaya N, Ahmadou D, Doudou D, Moustapha DM, Abdoul BS, Fatou GT, Malick NE, Madieye GP, Sidy K, Fatimata M, Fatou T, Alassane T, Babacar M, Gora D, Mbacke S, Philomène LS, Aynina C, Amadou DP, Oumar F and Alioune DYacouba D, Demba DJP, Rokhaya N, Ahmadou D, Doudou D, Moustapha DM, Abdoul BS, Fatou GT, Malick NE, Madieye GP, Sidy K, Fatimata M, Fatou T, Alassane T, Babacar M, Gora D, Mbacke S, Philomène LS, Aynina C, Amadou DP, Oumar F and Alioune D
  
  The proline rich domain of the P53 tumor suppressor protein is necessary for the induction of apoptosis. A common polymorphism, Proline-72-Arginine, alters structural and biological properties of P53 . The Arginine allele has been suggested as a risk factor for breast cancer. We investigate by association and segregation studies, the role of Arg72 allele as a risk factor in sporadic and familial breast cancer in Senegalese women. Eighty patients diagnosed with breast cancer followed up at the Curie Institute in Dakar, and eighty-five healthy controls without known cancer, were recruited after informed consent. For each individual, DNA was extracted from whole blood and codon 72 polymorphism genotyped by PCR-RFLP. Our results showed an increased risk for patients carrying Arg/ Arg and Arg/Pro genotypes compared to those carrying Pro/Pro (p<0.03). Similarly, the Arg.. Read More»
  DOI: 10.4172/1747-0862.1000300

  Abstract PDF