Journal of AIDS & Clinical Research

Phyllis C Tien

Publications

• Research Article
  Direct and Indirect Serum Markers of Liver Fibrosis Compared with Transient Elastography among Women in the Women's Interagency HIV Study
  Author(s): Seble Kassaye, Ying Li, Gregory Huhn, Marion G Peters, Audrey L French, Phyllis C Tien, Bruce Luxon and Michael W PlankeySeble Kassaye, Ying Li, Gregory Huhn, Marion G Peters, Audrey L French, Phyllis C Tien, Bruce Luxon and Michael W Plankey
  
  Objective: The aim of this study was to determine the test characteristics of direct and indirect biomarkers for liver fibrosis compared with transient elastography (TE) among a group of human immunodeficiency virus (HIV)-infected and uninfected women with or without Hepatitis C virus (HCV) infection. Methods: Women enrolled in the Women’s Interagency HIV Study (WIHS) from Washington DC, San Francisco, and Chicago with a body mass index (BMI)<35 underwent liver stiffness measurement using TE between October, 2010 and September, 2012. Serum samples were tested for hyaluronic acid to calculate the SHASTA and aspartate aminotransferase to platelet ratio index (APRI). Receiver operator characteristics (ROC) of significant liver fibrosis (liver stiffness ≥ 7.1 kPa by TE, correlating with a METAVIR fibrosis score of F2-F4) predicted by SHASTA and APRI .. Read More»
  DOI: 10.4172/2155-6113.1000446

  Abstract PDF